Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors

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Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors

Many vaccination strategies and immune cell therapies aim at increasing the numbers of memory T cells reactive to protective antigens. However, the differentiation lineage and therefore the optimal generation conditions of CD4 memory cells remain controversial. Linear and divergent differentiation models have been proposed, suggesting CD4 memory T cell development from naive precursors either w...

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t helper cell type-1 transcription factor t-bet is down-regulated in type 1 diabetes

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 2008

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.20071855